Regulation of Aryl Hydrocarbon Receptor Function by Selective Estrogen Receptor Modulators
نویسندگان
چکیده
منابع مشابه
Selective Estrogen Receptor Modulators
Selective estrogen receptor modulators (SERMs) are now being used as a treatment for breast cancer, osteoporosis and postmenopausal symptoms, as these drugs have features that can act as an estrogen agonist and an antagonist, depending on the target tissue. After tamoxifen, raloxifene, lasofoxifene and bazedoxifene SERMs have been developed and used for treatment. The clinically decisive differ...
متن کاملSelective estrogen receptor modulators (SERMS).
Hormone receptors and, specifically, estrogen receptors were described about four decades ago. For estrogens, there are two receptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta). The two receptors are coded by different genes and their tissue expression varies across organs. ERalpha is predominantly expressed in reproductive tissues (uterus, breast, ovaries) liver and...
متن کاملChemosensitization of Resistant Breast and Prostate Cancer Cells by Selective Aryl Hydrocarbon Receptor Modulators (sahrms)
Recent reports indicate that SAhRMs such as 3, 3’-diindolylmethane (DIM) inhibit α-estrogen receptor (ER) expression and estrogen signaling in human breast cancer cells and inhibit androgen receptor (AR) signaling in human prostate cancer cells. DIM is an AhR agonist derived from Brassica vegetables and has been shown to have antiproliferative and proapoptotic effects in breast and prostate can...
متن کاملEstrogen receptor and aryl hydrocarbon receptor signaling pathways
Estrogen receptors (ERs) and the aryl hydrocarbon receptor (AhR) are ligand activated transcription factors and members of the nuclear receptor and bHLH-PAS superfamilies, respectively. AhR is involved in xenobiotic metabolism and in mediating the toxic effects of dioxin-like compounds. Crosstalk has been observed among AhR and nuclear receptors, but has been most well studied with respect to E...
متن کاملPharmacophore Mapping of Selective Estrogen Receptor Modulators
Breast cancer and osteoporosis are the common manifestations of post-menopausal women, and estrogen is responsible for these diseases. Selective Estrogen Receptor Modulators (SERMs) act as selective agonist and/or antagonistic effects to the different tissues, and use as first line treatment in estrogen responsive breast cancer and osteoporosis. To design promising SERM, the present study has b...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2010
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2009-0339